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Home > Products >  Candesartan Cilexetil

Candesartan Cilexetil CAS NO.145040-37-5

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  • Candesartan Cilexetil
  • 145040-37-5
  • Candestartan

Quick Details

  • ProName: Candesartan Cilexetil
  • CasNo: 145040-37-5
  • Molecular Formula: C33H34N6O6
  • Appearance: White Solid
  • Application: It can be used as pesticide and pharma...
  • DeliveryTime: within one week after payment
  • PackAge: As required
  • Port: China main port
  • Purity: 99%
  • Storage: Avoid direct sunlight,cool and dry
  • Transportation: Express courier/ by air / by sea
  • LimitNum: 0
  • Related Substances: 0.5%max
  • Residue on Ignition: 0.2%max
  • Heavy Metal: 0.001%max
  • Valid Period: 2years


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Delivery :
1.Package will be shipped with 3 days after payment. We can send it via HKEMS, EUB, DHL .UPS, TNT.FedEx or other method.
2.We have a professional and stable logistics, We will decided to choose which courier depend on Different countries.To find the best way to delivery the goods for you.
3.If the goods were lost or not received for other reasons, please contact me Immediately.We will give you arrange resend.


Candesartan Cilexetil
Synonyms:Candesartan Cilexitil;1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-benzimidazole-7-carboxylate;1-(((cyclohexyloxy)carbonyl)oxy)ethylester,(+-)-henyl)-4-yl)methyl);Candestartan

Candesartan Cilexetil Chemical Properties

Chemical Properties White Solid
Melting point 168-170℃
Solubility DMSO: ≥15mg/mL

Candesartan Cilexetil Uses

Ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.

The precursor drug of Antihypertensive drug Candesartan---Candesartan cilexetil

Hypertension disease, due to its high incidence, high morbidity and high mortality as well as the resulted various kinds of issues including medical, social, family, economic, has changed from purely personal disease to serious social issues. Study and development of first-line drug treatment of hypertension has increasingly become the focus of the world's major competing focus of many major manufacturers. The main purpose of the treatment of hypertension is to minimize the total risk of cardiovascular disease death and disability with its goal being able to restore blood pressure to 140/90mmHg or less.
Currently, there are many kinds of clinical anti-hypertensive drugs and can be primarily divided into five categories, namely, diuretics, β-blockers, angiotensin-converting enzyme inhibitors (ACE-Ⅰ), calcium antagonists, and α-blockers. They all have certain limitations and side effects in use. Since the 1980s, ACE-I have been widely used to treat a variety of cardiovascular diseases and have been demonstrated to have excellent pressure-lowering effect on high blood pressure. However, since the ACE-Ⅰ also inhibits the degradation of bradykinin, and thus often resulting dry cough during the treatment of patients.
Currently, a new class of anti-hypertensive drugs-angiotensin Ⅱ receptor antagonist has been listed. A typical representative of such drugs includes losatran (Merck), valsartan (Novartis) and eprosartan (SmithKline). As the role of these drugs are more specific than the ACE-I, increasing the antihypertensive effect with reduced side effects as well as not causing cough. It also has protective effects on blood vessels, kidneys and heart. Therefore, this type of drug has become a competition protagonist in the hypertension drug market.
Candesartan cilexetil is the pro-drug of candesartan with the action strength being 10 times as high as losatran. Its action has a good selectivity (has a 10000 time higher affinity to AT1 receptor than AT2), long duration of action (take it one time daily). As a pro-drug, it can release its activity in a relatively mild way after oral administration, making it be a kind of ideal drug for treatment of hypertension.
According to the foreign prediction, the annual sales of this kind of goods can reach up to $ 2 billion so the development of this product will surely achieve good economic and social benefits.

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